Toxic epidermal necrolysis (skin) is the skin problem that manifests itself in the form of blisters and peeling in the mouth, eye or genital organs. Toxic epidermal necrolysis, which occurs as the most severe form of Stevens-Johnson syndrome, is caused by the reaction against drugs. This situation, which affects people of all ages and threatens life, needs to be treated in the hospital environment. While aiming to heal the skin during the treatment process, adequate fluid intake is also important.
What is toxic epidermal necrolysis (skin)?
Toxic epidermal necrolysis (skin) is a skin health disease that occurs in areas such as mouth, eyes and genital organs that manifests itself with symptoms of fever and flu in the first stage. Stevens-Johnson syndrome occurs as severe form of syndrome. Toxic epidermal necrolysis, also called Lyell syndrome, can cause large bubbles and peeling in the body. This causes serious damage to the surface of the skin causes fluid loss or infections so that it may be dangerous.
Toxic epidermal necrolysis (skin) can be caused by HIV virus and lymphoma, especially affecting people with weak immune system. It is a discomfort that can be seen in people of all ages, but it can affect the elderly more.
What are the symptoms of toxic epidermal necrolysis?
Symptoms of toxic epidermal necrolysis (skin) are a condition that can develop a few weeks after taking medication. Early symptoms may also manifest itself in the form of toxic epidermal necrolysis, headache and body pain.
Symptoms of toxic epidermal necrolysis can be listed as follows:
- Fire
- Cough
- Shake
- Body pain
- Headache
- Redness and inflammation of the eyes
Toxic epidermal necrolysis causes a painful skin rash in the form of large bubbles and peeled skin. While the skin is peeling, painful open wounds that look like burns begin to develop. These erosions are especially seen in the chest and face area. Usually it may spread to these parts of the body:
- Conjunctiva (interior of the eyelid) and cornea (outer lens of the eye)
- Mouth, nose, throat and respiratory tract
- Urinary tract, anus and genital area
These erosions can make it difficult to eat, swallow, breathe, see, urinate, and other functions.
What causes toxic epidermal necrolysis (skin)?
Toxic epidermal necrolysis, the trigger of certain drugs may result in the result. Infections in the body can also be listed among conditions that cause skin syndrome. In most cases, certain drugs can trigger skin syndrome. These drugs can be listed as follows:
- Drugs used to treat kidney stones and gout disease
- Anticonvulsites used to treat seizures
- Antiretroviral drugs used in HIV treatment
- Antiinflammatory drugs
In addition, other triggers include infections and vaccines. There may also be cases where the cause of skin syndrome cannot be explained.
How to diagnose toxic epidermal necrolysis (skin)?
Toxic epidermal necrolysis (skin) is an important skin problem to be diagnosed early. With the symptoms, the doctor makes a detailed assessment during the diagnosis process. The methods used in the diagnosis of toxic epidermal necrolysis are as follows:
- The doctor learns the medicines and symptoms used by examining the health history of the person.
- Toxic epidermal necrolysis, widespread skin rash, skin -filled blisters on the skin, peeling the skin and mucosal lesions are evaluated with symptoms
- Skin biopsy can be applied for definitive diagnosis and diagnosis
- Thanks to blood tests, infection, immune system response and organ functions are checked.
- If electrolyte imbalances and liver kidney function disorders are controlled, they are also controlled with symptoms.
- Finally, the doctor applies a slight pressure on the person’s skin and looks at whether the skin structure is peeled. Nikolsky, which is seen as positive, is typically considered for skin.
How is toxic epidermal necrolysis (skin) treated?
Toxic epidermal necrolysis (skin) is a condition that requires emergency medical intervention in the case of progress. Therefore, the treatment process is carried out in intensive care units or burns. The main treatment methods of toxic epidermal necrolysis are listed as follows:
- The use of drugs that may cause TEN is stopped immediately
- Fluid and electrolyte imbalances due to skin loss are provided by vein
- Due to mucosal lesions, oral feeding may become difficult. In this case, Enteral nutritional method is applied
- In case of severe pain, appropriate painkillers are controlled
- Since the risk of infection is high, sterile care is provided and symptoms of infection are closely monitored
- Immunoglobulin (IG) treatment can be used to suppress the immune response and reduce skin damage
- If there is eye involvement, a ophthalmologist must follow
Treatment of skin is a long -lasting process. It is a discomfort that requires careful monitoring during the recovery. It is possible to reduce complications with early diagnosis and appropriate treatment.
Frequently asked questions about toxic epidermal necrolysis (ten)
What are the long -term effects of toxic epidermal necrolysis?
Toxic epidermal necrolysis (skin) may also cause permanent effects after recovery. Visual loss especially in patients with eye involvement Or may experience problems such as chronic eye dryness. In addition, permanent traces on the skin, pigment changes and scar tissue in mucosal regions are likely to observe.
What does the diagnosis of skin mean?
The diagnosis of skin is determined to have a serious skin reaction. This is usually considered as the result of excessive immune response to certain drugs. Peeling the wide surfaces of the skin and the existence of the risk of serious complications are among the conditions that make this diagnosis critical.
